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microRNA(miRNA)是真核生物中一類內源性的小非編碼RNA,長度約為17~25bp。自1993年被發現miRNA以來,小RNA領域的進展和發現顛覆了科學界對基因調控的認識。從胚胎發育開始,到細胞凋亡,乃至腫瘤生長,miRNA在一系列生理和病理過程中發揮著重要的作用,各種遺傳、代謝、傳染病和腫瘤相關的miRNA為科學家進行病理研究提供了新的角度,可能成為可靠的疾病生物標志物,科學家們也正積極地通過改變miRNA的功能、研發新的體內遞送方法,尋求對疾病干預治療,miRNA近來還被發現用于介導跨物種的進化與適應,更多的miRNA還有待探索。

溫馨提示:除miRBase收錄的人、小鼠、大鼠之外,其他物種miRNA mimic、inhibitor、precursor產品為10 nmol起訂;含有末端修飾的siRNA、mimics、inhibitors、precursor最小起訂量為10nmol。

micrON? miRNA mimic 是運用化學方法合成的miRNA 模擬物,能模擬細胞中成熟miRNA …
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miRNA precursor是化學方法制備的miRNA 前體分子,是大約60-80nt 的莖環狀單鏈…
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micrOFF? miRNA inhibitor是化學合成經特殊修飾的miRNA 抑制劑,通過特異性結合成熟 …
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micrON? miRNA agomir是經過特殊化學修飾的miRNA激動劑,通過模擬內源性miRNA …
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micrOFF? miRNA antagomir是經過特殊化學修飾的miRNA拮抗劑,通過與體內的…
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基因文庫帶來了功能基因組學研究的效率革命,它實現了高通量、低成本、超快速的基因…
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參考文獻

[1] Zhou J, Xu J, Zhang L, et al. Combined single-cell profiling of lncRNAs and functional screening reveals that H19 Is pivotal for embryonic hematopoietic stem cell development[J]. Cell stem cell, 2019, 24(2): 285-298. e5. (IF21.464? 銳博產品:mimic? 研究領域:胚胎造血干細胞發育? 軍事醫學科學院)

[2] Li T, Guo H, Li H, et al. MicroRNA-92a-1–5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia[J]. Gut, 2019: gutjnl-2017-315318. (IF17.943? 銳博產品:mimic? 研究領域:胃腸上皮化生? 第四軍醫大學)

[3] Zhong F, Hu Z, Jiang K, et al. Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis[J]. Cell research, 2019: 1. (IF17.848? 銳博產品:mimic? 研究領域:酒精性肝損傷和脂肪變性? 廣西醫科大學第一附屬醫院)

[4] Qin X, Guo H, Wang X, et al. Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5[J]. Genome biology, 2019, 20(1): 12. (IF14.028? 銳博產品:mimic? 研究領域:頭頸癌? 上海交通大學醫學院第九人民醫院)

[5] Ying Z, Xiang G, Zheng L, et al. Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming[J]. Cell metabolism, 2018, 28(6): 935-945. e5. (IF22.415? 銳博產品:mimic? 研究領域:體細胞重編程? 中國科學院廣州生物醫藥與健康研究院)

[6] Zhou J, Xu J, Zhang L, et al. Combined single-cell profiling of lncRNAs and functional screening reveals that H19 Is pivotal for embryonic hematopoietic stem cell development[J]. Cell stem cell, 2019, 24(2): 285-298. e5. (IF21.464? 銳博產品:mimic? 研究領域:胚胎造血干細胞發育? 軍事醫學科學院)

[7] Li T, Guo H, Li H, et al. MicroRNA-92a-1–5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia[J]. Gut, 2019: gutjnl-2017-315318. (IF17.943? 銳博產品:mimic? 研究領域:胃腸上皮化生? 第四軍醫大學)

[8] Zhong F, Hu Z, Jiang K, et al. Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis[J]. Cell research, 2019: 1. (IF17.848? 銳博產品:mimic? 研究領域:酒精性肝損傷和脂肪變性? 廣西醫科大學第一附屬醫院)

[9] Qin X, Guo H, Wang X, et al. Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5[J]. Genome biology, 2019, 20(1): 12. (IF14.028? 銳博產品:mimic? 研究領域:頭頸癌? 上海交通大學醫學院第九人民醫院)

[10] Ying Z, Xiang G, Zheng L, et al. Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming[J]. Cell metabolism, 2018, 28(6): 935-945. e5. (IF22.415? 銳博產品:mimic? 研究領域:體細胞重編程? 中國科學院廣州生物醫藥與健康研究院)

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